2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P0236
    Neurokinin A(4-10) 97559-35-8
    Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.
    Neurokinin A(4-10)
  • HY-P0249
    Phe-Met-Arg-Phe, amide 64190-70-1
    Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
    Phe-Met-Arg-Phe, amide
  • HY-P0250
    Kassinin 63968-82-1
    Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.
    Kassinin
  • HY-P0255
    Physalaemin 2507-24-6
    Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
    Physalaemin
  • HY-P0268
    Myomodulin 110570-93-9
    Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
    Myomodulin
  • HY-19845A
    Ordopidine hydrochloride 871351-61-0
    Ordopidine hydrochloride is a modulator of dopamine receptor extracted from patent WO/2005/121087A1, compound example 2; exhibits an ED50 of 68 μmol/kg on increase of DOPAC in the rat striatum.
    Ordopidine hydrochloride
  • HY-U00204
    Nisobamate 25269-04-9
    Nisobamate (W1015) is a tranquilizer.
    Nisobamate
  • HY-U00207
    MEN11467 214487-46-4
    MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist.
    MEN11467
  • HY-U00240
    SA72 934809-60-6
    SA72 is a highly selective fatty acid amide hydrolase (FAAH) inhibitor.
    SA72
  • HY-U00241
    Carburazepam 59009-93-7
    Carburazepam is a agent which derives from benzodiazepine. Benzodiazepines (BZD, BZs) are a class of psychoactive agents whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
    Carburazepam
  • HY-U00250
    β-Amino Acid Imagabalin Hydrochloride 610300-00-0
    β-Amino Acid Imagabalin Hydrochloride (PD-0332334) is a ligand for the α2δ subunit of the voltage-dependent calcium channel.
    β-Amino Acid Imagabalin Hydrochloride
  • HY-U00294
    NEP-In-1 465527-94-0
    NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.
    NEP-In-1
  • HY-U00319
    Lipid peroxidation inhibitor 1 142873-41-4
    Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.
    Lipid peroxidation inhibitor 1
  • HY-U00322
    5-HT3 antagonist 3 120635-47-4
    5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM.
    5-HT3 antagonist 3
  • HY-U00327
    Prenyl-IN-1 360561-53-1
    Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
    Prenyl-IN-1
  • HY-U00334
    LH secretion antagonist 1 88531-67-3
    LH secretion antagonist 1 is an antagonist of luteinising hormone secretion, and may be used as an analgesic. LH secretion antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    LH secretion antagonist 1
  • HY-U00341
    ST4206 1246018-36-9
    ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research.
    ST4206
  • HY-101831
    Heterocyclyl carbamate derivative 1 168830-01-1
    Heterocyclyl carbamate derivative 1 is a heterocyclyl carbamate derivative that may be used for the research of inflammatory and neurological diseases.
    Heterocyclyl carbamate derivative 1
  • HY-15085A
    (Z)-MDL 105519 179105-67-0
    (Z)-MDL 105519 is the inactive isoform of MDL 105519.
    (Z)-MDL 105519
  • HY-19282A
    (5R)-BW-4030W92 189013-61-4
    (5R)-BW-4030W92 is the R enantiomer of BW-4030W92. BW-4030W92 is a non-selective, voltage-, and use-dependent sodium channel antagonist.
    (5R)-BW-4030W92
Cat. No. Product Name / Synonyms Application Reactivity